Publications

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Chowdhury, S., Hinchliffe, T., Castro, S., Coker, C., Arpaia, N.*, Danino, T.* Programmable bacteria induce durable tumor regression and systemic antitumor immunity.  Nature Medicine 25, 1057–1063 (2019)

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Harimoto, T., Singer, Z., Velazquez, O., Zhang, J., Castro, S., Hinchliffe, T., Mather, W., Danino, T. Rapid screening of engineered microbial therapies in a 3-D multicellular model. PNAS 1820824116 (2019)

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Gurbatri, C., Coker, C., Hinchliffe, T., Iona, L., Castro, S., Treuting, P., Arpaia, N., Danino, T. Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies. bioRxiv 562785 (2019)

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Zhu, S., Deb, D., Danino, T. A spatial cell culture model for predicting chemotherapy dosing strategies. bioRxiv 561746 (2019)

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Fedorec, A J.H., Ozdemir, T., Doshi, A., Rosa, L., Velazquez, O., Danino, T., Barnes, C P. Two new plasmid post-segregational killing mechanisms for the implementation of synthetic gene networks in E. coli. iScience (2019), https://doi.org/10.1016/j.isci.2019.03.019

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Ozdemir, T.,  Fedorec, A J.H., Danino, T., Barnes, C P. Synthetic Biology and Engineered Live Biotherapeutics: Toward Increasing System Complexity. Cell Systems 7 (1), 5-16 (2018)

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Geller, L.*, Barzily-Rokni, M.*, Danino, T., Shee, K., Thaiss, C., Livny, R., Avraham, R., Barczak, A., Zwang, Y., Mosher, C., Smith, D., Chatman, K., Skalak, M., Bu, J., Cooper, Z., Tompers, F., Ligorio, M., Qian, Z., Muzumdar, M., Michaud, M., Mandinova, A., Garrett, W., Jacks, T., Ogino, Gurbatri, C., S., Ferrone, C., Thayer, S., Warger, J., Trauger, S., Johnston, S., Huttenhower, C., Gevers, D., Bhatia, S., Golub, T. Straussman, R.  Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science  357 (6356), 1156-1160 (2017)

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Chien, T.*, Doshi, A.*, Danino, T. Advances in bacterial cancer therapies using synthetic biology. Current Opinions in Systems Biology 5, 1-8 (2017)


Moon, S.*, Fritz, I.*, Singer, Z.*, Danino, T. Controlling spatial patterning of bacteria via screen printing.  3D Printing and Additive Manufacturing. Dec 2016, 3(4): 194-203

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Din, O.*, Danino, T.*, Prindle, A., Skalak, M., Selimkhanov, J., Allen, K., Julio, E., Atolia, A., Tsimring, L., Bhatia, S., Hasty, J.  Synchronized cycles of bacterial lysis for in vivo delivery.  Nature 536(7614):81-85 (2016)


Luna, J., Scheel, T., Danino, T., Shaw, K., Takacs, C., Mele, A., Fak, J., Nishiuchi, E., Cantanese, M., Rice, C., Darnell, R.  Hepatitis C virus RNA functionally sequesters miR-122.  Cell  160(6), 1099–1110 (2015)


 Danino, T.*, Prindle, A.*, Kwong, G., Skalak, M., Li, H., Allen, K., Hasty, J., and Bhatia, S. Programmable probiotics for detection of cancer in urineSci. Transl. Med. 7, 289ra84 (2015) 


Danino, T.*, Prindle, A.*, Hasty, J., and Bhatia, S.  Measuring growth and gene expression dynamics of tumor-targeted S. typhimurium bacteria. Journal of Visualized Experiments 77, e50540 (2013)

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Prindle, A., Selimkhanov, J.S.,  Danino, T., Samayoa, P., Goldberg, A., Bhatia, S., and Hasty, J.  Synthetic biology in clinically relevant microbes. ACS Synthetic biology 1(10), 458-464 (2012)

 

Danino, T., Lo, J., Prindle, A., Hasty, J., and Bhatia, S.  In vivo gene expression dynamics from tumor-targeted bacteria. ACS Synthetic biology 1(10), 465-470 (2012)

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Cookson, N.A.*, Mather, W.H.*, Danino, T., Mondragón-Palomino, O., Williams, R. J., Tsimring, L. S., and Hasty, J.  Queueing up for enzymatic processing: Correlated signaling through coupled degradation. Molecular Systems Biology 7:561, (2011)

 

Prindle, A.*, Samayoa, P.*, Razinkov, I., Danino, T., Tsimring, L.S. and Hasty, J.  Sensing array of radically coupled genetic biopixels. Nature 481, 39-44 (2011)
 

Mondragon-Palomino, O., Danino, T., Selimkhanov, J., Tsimring, L.S., and Hasty, J.  Entrainment of a population of synthetic genetic oscillators. Science 333(6047), 1315-1319 (2011)


Boyer, D., Mather, W., Mondragon-Palomino, O., Orozco-Fuentes, S., Danino, T., Hasty, J., and Tsimring, L. S.  Buckling instability in ordered bacterial colonies. Physical Biology 8, 026008 (2011)
 

Danino,T., Volfson, D., Bhatia, S., Tsimring, L., and Hasty, J.  In-silico pattern formation of vascular mesenchymal stem-cells in three-dimensions. PLoS ONE 6(5), e20182 (2011)


Mather, W., Mondragon-Palomino, O., Danino, T., Hasty, J., and Tsimring, L.S.  Streaming instability in growing cell populations. 
Physical Review Letters 104(20), 208101 (2010)


Danino, T.*, Mondragon-Palomino, O.*, Tsimring, L., and Hasty, J.  A synchronized quorum of genetic clocks. Nature 463, 326-330 (2010)