DANINO LAB
Columbia University
Department of Biomedical Engineering

Synthetic Biological Systems Laboratory

Engineering
living
medicines.

We use synthetic biology to program microbes to sense, respond, and treat disease—advancing a new era of cooperative therapies.

Explore our research
Engineered bacteria interacting with a tumor microenvironment
Engineering Biology
for Human Health

Our lab engineers living systems that can sense their environment, compute biological information, and deliver therapeutic functions. We combine synthetic biology, microbial engineering, and quantitative approaches to develop next-generation cancer therapies, living diagnostics, and programmable biological systems.

01

Living
Medicines

Living medicines schematic

Engineered bacteria that selectively colonize tumors and deliver therapeutic payloads.

02

Synthetic
Biology

Synthetic biology genetic circuit schematic

Programmable genetic circuits that allow cells to sense, compute, and respond.

03

Cooperative
Therapies

Cooperative therapy schematic

Bacteria working with immune cells, oncolytic viruses, nanoparticles, and other therapeutic modalities.

04

Biological
Dynamics

Biological dynamics data schematic

Microscopy, sequencing, and computational approaches to understand and control living systems.