Engineering
living medicines
We program cells to sense, respond, and treat disease—advancing a new era of living therapies.
SYNTHETIC BIOLOGICAL SYSTEMS LABORATORY
Our lab approaches biology as an engineering discipline—one in which living systems can be measured, modeled, programmed, and redesigned for human health. We use synthetic biology and bioengineering approaches to understand how cells sense and respond to their environments and use those insights to design new medicines to ultimately improve outcomes for patients.
EXPLORE OUR RESEARCH→1
DESIGN
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BUILD
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TEST
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LEARN
Probiotic-guided CAR-T cells for solid tumor targeting
Science · 2023
A programmable encapsulation system improves delivery of therapeutic bacteria in mice
Nature Biotechnology · 2022
Probiotic neoantigen delivery vectors for precision cancer immunotherapy
Nature · 2024
Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies
Science Translational Medicine · 2020
Special delivery: bacterial couriers are smuggling drugs into cancers
Nature · 2026
Danino Lab receives the 2026 Lotus Award
Pershing Square Foundation · 2026
New weapons against cancer: millions of bacteria programmed to kill
The New York Times · 2019
Learn about the lab, opportunities to join the team, and where to find us on the Morningside campus.