Engineering
living medicines
We program cells to sense, respond, and treat disease—advancing a new era of living therapies.
Engineering biology
for human health
Our lab approaches biology as an engineering discipline—one in which living systems can be measured, modeled, programmed, and redesigned for human health. We use synthetic biology coupled with bioengineering and systems biology approaches to understand how cells sense and respond to their environments and use those insights to design new medicines that ultimately improve outcomes for patients.
Publications Highlights
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Probiotic-guided CAR-T cells for solid tumor targeting
Science · 2023
A programmable encapsulation system improves delivery of therapeutic bacteria in mice
Nature Biotechnology · 2022
Probiotic neoantigen delivery vectors for precision cancer immunotherapy
Nature · 2024
Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies
Science Translational Medicine · 2020
News Highlights
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New weapons against cancer: millions of bacteria programmed to kill
The New York Times · 2019
Bacteria deliver the goods
Nature Reviews Drug Discovery · 2022
About the Lab
Learn about the lab, opportunities to join the team, and where to find us on the Morningside campus.