http://daninolab.nyc/portfolio daily 0.75 2019-12-08 https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1438798304536-GGWPK0AZHMT0UW8RSNFB/News3x2_small.jpg portfolio - our lab in the news https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1438798304536-GGWPK0AZHMT0UW8RSNFB/News3x2_small.jpg portfolio - our lab in the news https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1438800215307-2XG4RK8SU7DIXHYYKZEP/Research3x2.jpg portfolio - READ MORE ABOUT OUR RESEARCH ON SYNTHETIC BIOLOGICAL SYSTEMS https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1563554111859-ZFIGC02AG9WT54UEOS8M/Publications3x2.1.png portfolio - READ more from our publication list https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1438799641973-532MZKQYEIBKEHS9VK64/People3x2.jpg portfolio - MEET members of OUR lab https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1438798613010-HM6DVEUIOTJ1JG05YE8Q/videos3x2.jpg portfolio - checkout our timelapse microscopic videos https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1438799929617-0VO94I5ULNPG9O1XVDT1/ArtOutreach3x2.jpg portfolio - LEARN more about our art and outreach projects http://daninolab.nyc/outreach daily 0.75 2023-10-31 https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1489209472873-Q3WWFDQX99J017B1EL2X/unspecified-1.jpeg Outreach - Bacteria Gallery https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1489209472873-Q3WWFDQX99J017B1EL2X/unspecified-1.jpeg Outreach - Bacteria Gallery https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1489182340684-KH0AZE7XP81MH3BM1ICS/kids_bacteria_8.jpg Outreach - Bacteria Outreach https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1438732642786-51SLF2FV4L6TMOM0WDGN/Colonies_SQ.jpg Outreach - COLONIES: LIVING CELLS AS ART https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1438732643777-J9UDL0K34VP3TQIQ5RP8/Petri_SQ.jpg Outreach - PETRI: BACTERIAL DISHWARE https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1438732643884-M7608MA9U0ZKLUDO5TX7/Syndemic_SQ.jpg Outreach - SYNDEMIC: A MICROBIAL VIDEO GAME https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1438732643868-AT2EJPO3TL8EPN409WNH/Supernova_SQ.jpg Outreach - THE SUPERNOVA & BLINKING BACTERIA https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1438732642850-8ILX0VLM79DTXPQBVIQW/CSV_SQ.jpg Outreach - COOL SCIENCE VIDEOS: A WEBSITE FOR SHARING SCIENCE VIDEOS https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1438732642702-7RK1IQCLDU4I8OGGQROS/BioFlashMob3_SQ.jpg Outreach - BIO FLASH MOBS & COMMUNITY EVENTS http://daninolab.nyc/petri daily 0.75 2023-10-31 https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1439930361156-NU98UFCC4RTPR3TUGD6P/image-asset.jpeg Petri https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1439930572545-S8E10KB7QI6BQDPU9JFJ/Bacteria+Chirality.JPG Petri https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1439930574014-R94OU5KG6W9ZXWBOUTLP/Chiral+Colony.JPG Petri https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1439930574461-USKESAWLOEGITRWDAM29/Chiral+Jam.JPG Petri https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1439930580393-YJI3CKO07S2FLQFAGYWC/Vik%2BMuniz%2BInvitation%2Bp1.png Petri https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1439930579145-LKKJSGJWKMYT9QHORJJ5/Tepid+Tip-Splitters.JPG Petri https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1439930575171-FQQZFNOZDWNV2Y9JVN4K/Diffuse+Salmonella.JPG Petri 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https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1457804955750-D2PEKZA2WZ4RUR4ROVND/DETAIL_VM-HeLa-Pattern-1.jpg colonies https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1457804957957-JBV14IOB0BH68QME3X32/DETAIL_VM-Huh75-Flowers-Gates.jpg colonies https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1457804960947-Z4ORFONO0SCVZK5C88JP/DETAIL_VM-Huh75-Flowers.jpg colonies https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1457804962879-PJN65K701E6N3WZF2G84/DETAIL_VM-iPS_Motherboard.jpg colonies https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1457804963600-4X4J8RNZLPAJB31X2DZR/DETAIL_VM-iPS-Pattern3.jpg colonies https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1457804968183-D954HD9IIGUN4UFV9F0T/DETAIL_VM-Liver-Crowd.jpg colonies https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1457804965521-63NXPF3VDIQA1FPKL9HY/DETAIL_VM-Liver-Pattern-1.jpg colonies http://daninolab.nyc/positions daily 0.75 2025-08-28 https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1439992947303-EVZH1KS2T1QTDX9G0WS4/image-asset.jpeg Positions Northwest Corner Building, Columbia University, New York City http://daninolab.nyc/research daily 0.75 2025-11-19 https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/a2deca26-27e3-40e1-aff5-11f3c9f23d6e/overview2.jpg Research Overview of the Danino lab. We use a multi-scale synthetic biology approach to engineer living medicines. We focus on programming bacteria as a cancer therapy, where microbes sense tumors and locally deliver therapeutics. https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1af4a5cb-9a21-49de-af8c-17df8f7adac8/procar.png Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/4e6417cf-883c-4748-8f49-096b3e036959/Pmirabilis.png Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/0b977443-4e61-4242-b3fe-8b87980d1cb7/micro.png Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1471887737982-4W3BWDG1ZP5SKYTTP53E/image-asset.png Research What if we could create a probiotic, edible bacteria that was "programmed" to find liver tumors? Tal Danino's insight exploits something we're just beginning to understand about bacteria: their power of quorum sensing, or doing something together once they reach critical mass. Danino, a TED Fellow, explains how quorum sensing works — and how clever bacteria working together could someday change cancer treatment. http://daninolab.nyc/new-page daily 0.75 2018-07-29 http://daninolab.nyc/people daily 0.75 2026-01-13 https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1501595388977-QS8OV4INN5ASB2O3HN0L/image-asset.jpeg People Tal Danino, Principal Investigator https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/7fec20fe-857b-4853-ab35-3ef0d97fb89c/IMG_1256%252525252Bcopy.jpg People Ed Ballister, Associate Research Scientist w/Arpaia Lab https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1629900311370-LTVLKSPZO1GPI41DLKPY/IMG_5881.JPG People - Make it stand out Sophia Windemuth, Phd Student https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1629218385845-Y9D3YUHYD8WL0LKU7T5S/Jade-Peres+2021.jpg People Jade Pereira de Andrade Peres, Research Operations Director https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/67af313e-cedf-488d-aecf-dc3808ac1e8d/new.jpg People Jaeseung Hahn, Associate Research Scientist https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/9afee681-d836-4ee7-a191-9f37e5e39c94/IMG_20240905_154529%7E5+%282%29.jpg People - Make it stand out Myra Asraf, PhD student https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1630439441970-CH74UBO8IYTTLKDKKHCM/0001.jpg People - Make it stand out Meghna Komaranchath, Phd Student https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1501170449626-OSKJBWQ5GM49LJZRNX92/courtney.jpg People Courtney Coker, Staff Associate https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/3f953d7c-6293-48f0-87c5-868ca8ce6001/Alex-Danino-webpage.jpg People - Make it stand out Alexander Michels, Postdoctoral Scientist https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/0a820377-f475-442c-9323-191a8f18d0f0/1000017445-modified+%281%29.jpg People - Make it stand out Arnav Tayal, PhD student https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/f20c7196-0017-4837-9462-e723d0cb515e/Image+from+iOS+%281%29.jpg People - Make it stand out Shunyu Huang, Phd Student https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/4d7567cf-d905-4e12-86c5-f321dffda0d0/ID+photo+-+Hannah+Kim+.jpg People - Make it stand out Hannah Kim, Research Assistant https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/53fc39f3-8480-4569-a2b9-1f60c8df922d/PXL_20250204_234906936%7E3.jpg People - Make it stand out Filippo Liguori Postdoctoral Scientist https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1576784394893-R9N3Z2ZWX5FBIH4NBXM5/IMG_5225%2525252Bcopy.jpg People Linda Chen, Phd Student https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1eda25ca-03b1-4d63-8406-4d6d830d5b77/Azra_BW+%281%29.jpg People - Make it stand out Azra Haseki, PhD student https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/02c7cf23-3381-4d89-ad0f-fc8532e956c0/IMG_9615.jpg People - Make it stand out Eleni Savidis, Research Assistant https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1598632649469-ENPR17GOWOGPV5W0M3GP/IMG_7415.jpg People Jongwon Im, Postdoctoral Scientist https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/3a18196c-9798-4ca5-8065-e4ff4e713cf0/Screen+Shot+2020-09-14+at+3.33.17+PM.jpg People Marian Shaw, Phd Student https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1513364038943-VSF3CRNBRHIJBQS30BPK/Untitled-1.jpg People Cooper, Lab Manager https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/7532fec8-f1ca-4a5d-a76b-c6f537bfbbc8/IMG_2824.jpg People - Make it stand out Rain Hu, Research Assistant https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/70ef96ba-fb86-49a2-bbe9-3f23862a89db/Untitled64_20240908224419.png People - Make it stand out Sara Hoggatt, PhD student https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/3812fbc8-2d35-4f99-8278-1aa49b1f9ea9/IMG_9221.jpg People Zeren (Franklin) Sheng, Phd Student https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/157afa63-6b7b-49bb-9705-b5f41fcea5bd/image0.jpg People - Make it stand out Lauren Goralsky, Undergraduate https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/f4c7e8fd-0614-4ea5-ac28-d480274722fd/labphoto.jpg People - Make it stand out Julia Rae Kirby, Undergraduate https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/76acb275-b949-4970-9edd-7314478e200e/Kailyn+Senior+Photo+2022-modified.jpg People - Make it stand out Kailyn Grant, Undergraduate https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/047bab73-827f-46cd-b390-065f90363368/Mia+Headshot.jpg People - Make it stand out Mia Raneri, Undergraduate https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/d4345f4f-c1fa-442a-befe-d5a11d83a7c7/charlize+photo+.jpg People - Make it stand out Charlize Szeto, Undergraduate https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/a3d9e778-5450-4229-8f91-81ab743f58d3/IMG_0303.jpg People - Make it stand out Mary Zawalick, Undergraduate https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/aac2f60c-db2f-4ca9-a0c0-89b604c3839c/IMG_1966.jpg People - Make it stand out Stephanie Tarrab, Undergraduate https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/e57038ac-8bda-4133-9a69-11a5892a415f/Kevin+Xu+Headshot.jpg People - Make it stand out Kevin Kai Xu, Undergraduate https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1b3fb19b-b63b-46d1-b48d-da8b6da7579d/Audrey+Lam+Photo.jpg People - Make it stand out Audrey Lam, Undergraduate https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/51552539-0acf-40f2-a9f8-326b7fa46c8c/Lu%2C+Amy+Headshot+%28black+and+white%29.jpg People - Make it stand out Amy Lu, Undergraduate https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/da7adbb2-65e2-42e1-9dab-7d4e51fb0f2c/headshot%281%29.jpg People - Make it stand out Demetrius Jackson, Undergraduate https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/ae61f362-ffd4-45be-a589-4444e2789f10/IMG_4364.jpg People - Make it stand out Veni Dole, Undergraduate http://daninolab.nyc/news daily 0.75 2026-01-13 https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/58a00458-a86d-4c77-a5a2-9805c167b63a/Screen+Shot+2022-12-02+at+11.10.28+AM.png News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/45eac76d-f58e-4d9d-82e5-fc573b68aa10/bacteria.jpg News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/30254597-c5b9-4723-aa51-f534f127945a/image%2B%287%29.jpg News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/07e5effc-57f7-4d05-9bd0-0a4af03403f7/microbial-rainbow_1600px.jpg News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/00495b3a-6cde-42e5-b4d7-b77b74b7b6f5/Screen+Shot+2022-12-02+at+11.02.27+AM.png News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/e266be35-998b-495e-9508-496f29b96520/VM-HeLa-Pattern-1.jpg News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. http://daninolab.nyc/taldanino daily 0.75 2025-09-02 https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/554c4263-1bcc-499d-9090-ffba2c693467/Tal+Danino.jpeg taldanino http://daninolab.nyc/bacteria-outreach daily 0.75 2023-10-31 https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1488842943098-3NAHO5MGUM9B40UNOOFJ/image-asset.jpeg BacteriaOutreach https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1488843087815-SB22OCZXGWWZTNUJZYV8/IMG_2175.jpeg BacteriaOutreach https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1488843101810-NASOS1QKBI0LEPGLCYHG/IMG_2191.jpeg BacteriaOutreach 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Microuniverse https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1489208522259-VADWUWD8KYTRUUCC97SQ/10.jpg Microuniverse https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1489208587443-HOEZV0AJ1FGFXT1MZZYW/11.jpg Microuniverse https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1489208661549-3SWDMQPEOOFIS9GUIJND/19.jpg Microuniverse https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1489208752861-FZQB619EW82KQTV6CCR3/13.jpg Microuniverse https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1489207960242-H7OMNW9IYS0H4V9JD4KV/4.jpg Microuniverse https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1489208030645-0IAUJMCXVNZ5ILLKOUVA/12.jpg Microuniverse https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1489207748053-FVH96ESYYWBOSX93T7MN/15.jpg Microuniverse http://daninolab.nyc/donate daily 0.75 2022-11-24 https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1510710311295-GF2YPMWPKWRSPWYF92U4/breast+cancer+ribbon_histology+copy.jpg Donate http://daninolab.nyc/research-1 daily 0.75 2018-09-29 https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1471887737982-4W3BWDG1ZP5SKYTTP53E/image-asset.png Copy of Research What if we could create a probiotic, edible bacteria that was "programmed" to find liver tumors? Tal Danino's insight exploits something we're just beginning to understand about bacteria: their power of quorum sensing, or doing something together once they reach critical mass. Danino, a TED Fellow, explains how quorum sensing works — and how clever bacteria working together could someday change cancer treatment. https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1469624480727-ZI3E3TT0MXPE8KMHPJML/SLC.jpg Copy of Research a, The circuit contains an activator and lysis plasmid. When the population reaches the quorum threshold at a critical AHL concentration, the luxI promoter drives the transcription of gene E for lysis,luxI, and sfGFP or luxCDABE as the reporter module. The luxI or the tac promoter also drives the transcription of the therapeutic gene for the stabilized circuit used in vivo. LuxR in this system is driven by the native luxR promoter. b, The main stages of each lysis cycle from seeding to quorum ‘firing’. Shown below the schematic depictions are typical time series images of the circuit-harbouring cells undergoing the three main stages of quorum firing in a microfluidic growth chamber. c, Fluorescence profile of a typical microfludic experiment. The estimated cell population trajectory reveals that lysis events correspond to peaks of sfGFP fluorescence. d, Period as a function of estimated flow velocity in the media channel of the microfluidic device and environmental temperature. Error bars indicate ± 1 s.d. for 13–50 peaks. These experiments were performed with strain 1, see Supplementary Information for complete strain information. https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1438263600809-Z98YYLT2J408RNDHUTD4/image-asset.jpeg Copy of Research PROP-Z (Programmable Probiotics with lacZ) for noninvasive cancer detection. The PROP-Z diagnostic platform is made up of probiotic EcN bacteria transformed with a dual-stabilized, high-expression lacZ vector as well as a genomically integrated luxCDABE cassette that allows for luminescent visualization without providing exogenous luciferin (blue). (1) PROP-Z is delivered orally. (2) Probiotics rapidly (within 24 hours) translocate across the gastrointestinal tract and (3) specifically amplify within metastatic tumors present in the liver. (4) PROP-Z expresses high levels of the enzyme lacZ (red), which can cleave systemically injected, cleavable substrates (green and yellow). Cleavage products of the substrates (yellow) filter through the renal system (5) into the urine for detection (6). https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1438263655979-T2N0O7GKEZ9QP72U1KRS/image-asset.jpeg Copy of Research Synchronized genetic clocks. (A) Network diagram. The luxI promoter drives production of the luxI, aiiA and yemGFP genes in three identical transcriptional modules. LuxI enzymatically produces a small molecule AHL, which can diffuse outside of the cell membrane and into neighbouring cells, activating the luxI promoter. AiiA negatively regulates the circuit by acting as an effective protease for AHL. (B) The "Supernova". Fluorescence microscopy overlay of a growing colony in a microfluidic device at the time it reaches a quorum. (C) Fluorescence slices of a typical experimental run demonstrate synchronization of oscillations in a population of E. coli residing in the microfluidic device (Movie in Videos page). Inset in the first snapshot is a ×100 magnification of cells. https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1438263709927-LEQR38D337NDNP6HDNWK/image-asset.jpeg Copy of Research Entrainment of genetic oscillators. (A) Architectures of eukaryotic circadian clocks and bacterial synthetic oscillators contain positive- and negative-feedback loops that are sensitive to external stimuli. (B) Fluorescence images from a time-lapse experiment show coherent GFP oscillations (green) in a colony of single-cell oscillators subject to a 30-min cycle of arabinose (red) (movie S1). (C)Fluorescence time series of a single-cell oscillator (green). The concentration of arabinose (red) changes sinusoidally according to [ara](t) = 0.3 + Asin(2πt/Tf) [percent weight/volume (% w/v)], with A = 0.15% and Tf = 30 min. The intensity plot above the graph corresponds to the cell trace. a.u., arbitrary units. (D) Fluorescence intensity plots of free-running and forced oscillators. (E) Entrainment regions indicate which forcing periods (Tf) and amplitudes (A) result in locking of the oscillator according to a deterministic model (SOM text). Entrainment of order 2:1 means that two oscillation peaks are observed for one peak of arabinose. https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1438263743123-LG9YNLM7KVJ9QPDBW5TW/Biopix1.jpg Copy of Research Bacteria "biopixels". (A) Network diagram. The luxI promoter drives expression of luxI, aiiA, ndh and sfGFP (superfolder variant of GFP) in four identical transcription modules. The quorum-sensing genes luxI and aiiA generate synchronized oscillations within a colony via AHL. The ndh gene codes for NDH-2, an enzyme that generates H2O2 vapour, which is an additional activator of the luxI promoter. H2O2 is capable of migrating between colonies and synchronizing them. (B) Conceptual design of the sensing array. AHL diffuses within colonies while H2O2 migrates between adjacent colonies through the PDMS. Arsenite-containing media is passed in through the parallel feeding channels. (C) Fluorescent image of an array of 500 E. coli biopixels containing about 2.5 million cells. Inset, bright-field and fluorescent images display a biopixel of 5,000 cells. (D) Heat map and trajectories depicting time-lapse output of 500 individual biopixels undergoing rapid synchronization. Sampling time is 2 min. https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1438263024511-RRMJKK5TFFEF7TBJ9NNX/image-asset.gif Copy of Research Dynamics of Tumor-Targeted Bacteria. (Left) S. typhimurium are injected via tail vein into nude mice and localize to subcutaneous tumors where they replicate. (Right) Sequence of IVIS images for an S.Typhimurium strain with a luminescent plasmid at 10^6 dosage over the course of 60 h. The IVIS signal rises due to rapid bacterial growth and then decays due to plasmid loss and luciferase instability. https://images.squarespace-cdn.com/content/v1/55b92910e4b0f072f1b20a45/1438263775227-8928DEQAHBYIZ9MQS4EI/PLoS1.jpg Copy of Research 3d pattern formation of vascular mesenchymal cells. (A) Interactions between BMP-2, MGP, and cells in culture. The binding of a BMP-2 dimer to receptors R and S stimulates production of BMP-2 and MGP, while the inding of MGP to BMP-2 outside of the cell prevents this process. (B) The derived model shows spherical spots (k = 0.2,c = 0.12), tubes (k = 0.2,c = 0.04), and sheet-like structures (k = 0.8,c = 0.04) by varying k and c. The parameters used were D = 0.005, q = 0.003, K = 0.25, B = 1.1, γ = 600 and the box length of the simulation is equivalent to 1 cm. 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